abstract：BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) is a common and severe form of stroke but is scarcely studied in young adults. Our aim was to study risk factors, clinical presentation and early mortality of ICH in the young and compare these features with older patients. METHODS:All consecutive patients aged bet...

journal_title：European journal of neurology

authors： Koivunen RJ,Satopää J,Meretoja A,Strbian D,Haapaniemi E,Niemelä M,Tatlisumak T,Putaala J

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Chronic kidney disease (CKD) is associated with a higher risk of stroke and atrial fibrillation (AF). There are limited data on the comorbidity of renal dysfunction and AF in stroke patients. Our aim was to determine the frequency of kidney dysfunction in ischaemic stroke patients with and withou...

journal_title：European journal of neurology

authors： Laible M,Horstmann S,Rizos T,Rauch G,Zorn M,Veltkamp R

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Alternating hemiplegia of childhood (AHC) is a rare neurological disease characterized by recurrent paroxysmal attacks of hemiplegia. The aim of the study was to assess the recovery cycle of the somatosensory evoked potentials (SEPs) in a group of AHC patients. METHODS:Seven AHC patients and 10 ...

journal_title：European journal of neurology

authors： Vollono C,Rinalduzzi S,Miliucci R,Vigevano F,Valeriani M

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cognitive impairment (CI) is found in about half of the multiple sclerosis (MS) population and is an important contributor to employment status and social functioning. CI is encountered in all disease stages and correlates only moderately with disease duration or Expanded Disability Status Scale ...

journal_title：European journal of neurology

authors： Van Schependom J,D'hooghe MB,Cleynhens K,D'hooge M,Haelewyck MC,De Keyser J,Nagels G

更新日期：2014-09-01 00:00:00

abstract：:Our aim was to conduct a meta-analysis of longitudinal studies assessing the association between Pittsburgh compound B (PiB) retention and the progression of cognitive status in healthy elderly, in patients with mild cognitive impairment (MCI) and in patients with Alzheimer's disease (AD). PubMed, MEDLINE, Embase and ...

journal_title：European journal of neurology

authors： Chen X,Li M,Wang S,Zhu H,Xiong Y,Liu X

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with ischaemic stroke (IS) caused by a spontaneous cervical artery dissection (CeAD) worry about an increased risk for stroke in their families. The occurrence of stroke in relatives of patients with CeAD and in those with ischaemic stroke attributable to other (non-CeAD) causes were com...

journal_title：European journal of neurology

authors： Kloss M,Grond-Ginsbach C,Pezzini A,Metso TM,Metso AJ,Debette S,Leys D,Dallongeville J,Caso V,Thijs V,Bersano A,Touzé E,Bonati LH,Tatlisumak T,Arnold ML,Lyrer PA,Engelter ST,Cervical Artery Dissection and Ischemic Stroke

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Spastic pes equinovarus is a frequent pathological posture of the lower extremity. Botulinum toxin (BoNT/A) has been successfully applied to treat lower limb spasticity. However, the best time to initiate treatment remains unclear. A beneficial effect of an early treatment has been suggested in p...

journal_title：European journal of neurology

authors： Fietzek UM,Kossmehl P,Schelosky L,Ebersbach G,Wissel J

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Comorbidity in myasthenia gravis (MG) is important for diagnosis, treatment and prognosis. Disease complexity was assessed by examining total drug treatment, immune therapy and comorbidity in a complete national MG cohort. METHODS:All recipients of the MG-specific drug pyridostigmine 2004-2010 r...

journal_title：European journal of neurology

authors： Andersen JB,Owe JF,Engeland A,Gilhus NE

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Migraine pathophysiology involves a complex interplay of processes wherein the hormonal, neurotransmitter and inflammatory pathways interact to influence the migraine phenotype. However, all studies pertaining to the role of genetic variants in migraine have been restricted to a specific pathway ...

journal_title：European journal of neurology

authors： Ghosh J,Pradhan S,Mittal B

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Accumulation of iron (Fe) is often detected in brains of people suffering from neurodegenerative diseases. However, no studies have compared the Fe load between these disease entities. The present study investigates by T2*-weighted gradient-echo 7.0 T magnetic resonance imaging (MRI) the Fe conte...

journal_title：European journal of neurology

authors： De Reuck JL,Deramecourt V,Auger F,Durieux N,Cordonnier C,Devos D,Defebvre L,Moreau C,Caparros-Lefebvre D,Leys D,Maurage CA,Pasquier F,Bordet R

更新日期：2014-07-01 00:00:00

abstract：:The aim of this narrative review is to evaluate the pathogenesis, clinical features, diagnosis, treatment and prognosis of intracranial artery dissection (IAD). IAD is a rare and often unrecognized cause of stroke or subarachnoid haemorrhage (SAH), especially in young adults. Two types of IAD can be identified: a subi...

journal_title：European journal of neurology

authors： Sikkema T,Uyttenboogaart M,Eshghi O,De Keyser J,Brouns R,van Dijk JM,Luijckx GJ

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cognitive impairment is common in Parkinson's disease (PD), even in the early stages. We aimed to assess the relationship between insulin-like growth factor-1 (IGF-1) and cognitive functions in early, drug-naïve patients with PD. METHODS:Serum IGF-1 was measured in 65 early, drug-naïve patients ...

journal_title：European journal of neurology

authors： Pellecchia MT,Santangelo G,Picillo M,Pivonello R,Longo K,Pivonello C,Vitale C,Amboni M,De Rosa A,Moccia M,Erro R,De Michele G,Santoro L,Colao A,Barone P

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To evaluate the association between having non-thymoma myasthenia and the risk of extra-thymic cancer in a population-based setting. METHODS:A nationwide case-control study was conducted in Denmark based on medical registries. The study included all cases with a first time diagnosis of cancer du...

journal_title：European journal of neurology

authors： Pedersen EG,Pottegård A,Hallas J,Friis S,Hansen K,Jensen PE,Gaist D

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The etiological classification of patients with transient ischaemic attack (TIA) is a difficult endeavor and the use of serum biomarkers could improve the diagnostic accuracy. The aim of this study was to correlate atrial fibrillation, the main cardioembolic etiology (CE), with different serum bi...

journal_title：European journal of neurology

authors： Purroy F,Suárez-Luis I,Mauri-Capdevila G,Cambray S,Farré J,Sanahuja J,Piñol-Ripoll G,Quílez A,González-Mingot C,Begué R,Gil MI,Fernández E,Benabdelhak I

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The ataxias are a challenging group of neurological diseases due the aetiological heterogeneity and the complexity of the genetic subtypes. This guideline focuses on the heredodegenerative ataxias. The aim is to provide a peer-reviewed evidence-based guideline for clinical neurologists and oth...

journal_title：European journal of neurology

authors： van de Warrenburg BP,van Gaalen J,Boesch S,Burgunder JM,Dürr A,Giunti P,Klockgether T,Mariotti C,Pandolfo M,Riess O

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Increased arterial stiffness causes vessel damage in the end-organs. Therefore small vessels in the brain may be susceptible to increased arterial stiffness. Cerebral microbleeds (CMBs) are topographically or pathophysiologically categorized as deep or infratentorial type and strictly lobar type....

journal_title：European journal of neurology

authors： Song TJ,Kim J,Kim YD,Nam HS,Lee HS,Nam CM,Heo JH

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Venous drainage of dural arteriovenous fistula (DAVF) with dementia has never been reported. The aim of this study was to discover if specific vascular conditions exist to develop dementia in patients with DAVF. METHODS:Venous drainage in patients embolized in our centre between 1996 and 2012 fo...

journal_title：European journal of neurology

authors： Labeyrie MA,Lenck S,Saint-Maurice JP,Bresson D,Houdart E

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To assess the efficacy and safety of olesoxime, a molecule with neuroprotective properties, in patients with amyotrophic lateral sclerosis (ALS) treated with riluzole. METHODS:A double-blind, randomized, placebo-controlled, multicenter trial of 18 months' duration was conducted in 512 subjects, ...

journal_title：European journal of neurology

authors： Lenglet T,Lacomblez L,Abitbol JL,Ludolph A,Mora JS,Robberecht W,Shaw PJ,Pruss RM,Cuvier V,Meininger V,Mitotarget study group.

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Subthreshold depression (SubD) is characterized by clinically relevant depressive symptoms not meeting criteria for major depression. The possible association of SubD with subjective cognitive complaints and/or objective cognitive impairments was investigated in a sample of consecutive, non-demen...

journal_title：European journal of neurology

authors： Santangelo G,Vitale C,Trojano L,Angrisano MG,Picillo M,Errico D,Agosti V,Grossi D,Barone P

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Migraine is a common neurological disorder. It can be divided into episodic migraine (EM) and chronic migraine (CM), based on headache frequency. Some studies have shown that insulin sensitivity is impaired in migraine; moreover, hypertension, diabetes and obesity are common in patients with CM. ...

journal_title：European journal of neurology

authors： Fava A,Pirritano D,Consoli D,Plastino M,Casalinuovo F,Cristofaro S,Colica C,Ermio C,De Bartolo M,Opipari C,Lanzo R,Consoli A,Bosco D

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Benign paroxysmal positional vertigo (BPPV) is a frequently encountered condition that can severely affect the quality of life. In this study, we aimed to assess the possible relations between serum uric acid (SUA) levels and BPPV. METHODS:Fifty patients with BPPV, and 40 age- and sex-matched co...

journal_title：European journal of neurology

authors： Celikbilek A,Gencer ZK,Saydam L,Zararsiz G,Tanik N,Ozkiris M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebral small vessel disease that may lead to disability and whose phenotype modulators are still unknown. METHODS:In the MIcrovascular LEukoencephalopathy Study (MILES), we asse...

journal_title：European journal of neurology

authors： Ciolli L,Pescini F,Salvadori E,Del Bene A,Pracucci G,Poggesi A,Nannucci S,Valenti R,Basile AM,Squarzanti F,Bianchi S,Dotti MT,Adriano E,Balestrino M,Federico A,Gandolfo C,Inzitari D,Pantoni L

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Acute severe exacerbations of myasthenia gravis (MG) are common in both early and late onset MG. We wished to examine the current management in the intensive care unit (ICU) of severe exacerbations of MG and to study the long-term prognosis of MG following discharge from the ICU. METHODS:We retr...

journal_title：European journal of neurology

authors： Spillane J,Hirsch NP,Kullmann DM,Taylor C,Howard RS

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Non-Western immigrants to Norway acquire an increased risk of multiple sclerosis (MS) after migration. Ethnicity and the presence of oligoclonal bands (OCBs) in the cerebrospinal fluid (CSF) might influence the disease course. The aim of this study was to investigate differences in disease severi...

journal_title：European journal of neurology

authors： Berg-Hansen P,Smestad C,Sandvik L,Harbo HF,Celius EG

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Autoantibodies (abs) to glutamic acid decarboxylase (GAD) and to voltage-gated potassium channels (VGKC) induce distinct courses of limbic encephalitis, related to MRI findings, seizure outcome and cognition. METHODS:A detailed analysis of the cognitive course of the two forms is presented, span...

journal_title：European journal of neurology

authors： Frisch C,Malter MP,Elger CE,Helmstaedter C

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The differences in the characteristics of thymus histology, coexisting autoimmune diseases and related autoantibodies between anti-muscle-specific receptor tyrosine kinase (MuSK)-antibody (Ab)-positive myasthenia gravis (MG) patients, and anti-acetylcholine receptor (AChR)-Ab-positive MG patients...

journal_title：European journal of neurology

authors： Nakata R,Motomura M,Masuda T,Shiraishi H,Tokuda M,Fukuda T,Ando T,Yoshimura T,Tsujihata M,Kawakami A

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Despite advances in the understanding of Huntington's disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation, however, appears to impact disease progression. Here we show the feasibility, safety and efficacy of a 9-month multidisciplinary rehabilitation programme in a small...

journal_title：European journal of neurology

authors： Thompson JA,Cruickshank TM,Penailillo LE,Lee JW,Newton RU,Barker RA,Ziman MR

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Previous antiplatelet therapy (APT) in cardiovascular prevention is common in patients with first-ever stroke. We aimed to evaluate the prognostic value of APT on early outcome in stroke patients. METHODS:All first-ever strokes from 1985 to 2011 were identified from the population-based Stroke R...

journal_title：European journal of neurology

authors： Béjot Y,Aboa-Eboulé C,de Maistre E,Jacquin A,Troisgros O,Hervieu M,Osseby GV,Rouaud O,Giroud M

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The association between past stroke subtypes and recurrent stroke subtypes in non-cardiogenic stroke remains unknown. METHODS:Patients with ischaemic stroke who had a past history of large-artery disease (LAD) or small-artery disease (SAD) subtypes were assessed. LAD was subdivided into intracra...

journal_title：European journal of neurology

authors： Yoon Y,Lee DH,Kang DW,Kwon SU,Suh DC,Bang OY,Kim JS

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Several small retrospective studies have observed that patients with a purely ocular manifestation of myasthenia gravis (MG) are significantly less likely to convert to a generalized disease when treated early on with corticosteroids. However, given the limited number of reported patients in the ...

journal_title：European journal of neurology

authors： Zach H,Cetin H,Hilger E,Paul A,Wuschitz B,Jung R,Auff E,Zimprich F

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a distinct epileptic syndrome with a broad range of severity even amongst affected members of the same pedigree, and the level of pharmacoresistance may reach 30%, close to that seen in sporadic focal epilepsies. METHODS:To investiga...

journal_title：European journal of neurology

authors： Labate A,Mumoli L,Fratto A,Quattrone A,Gambardella A

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:We investigated whether the prevalence of primary headaches was higher in patients with primary Sjøgren's syndrome (PSS) than in healthy individuals. METHODS:This retrospective cohort study included 71 patients with PSS (patients) based on the American European Consensus Classification criteria, and 71 age-...

journal_title：European journal of neurology

authors： Tjensvoll AB,Harboe E,Gøransson LG,Beyer MK,Greve OJ,Kvaløy JT,Omdal R

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Epilepsy is a frequent complication of central nervous system (CNS) infections. Post-infectious epilepsy is commonly refractory to medical treatment and plays a pivotal role for the poor long-term outcome of CNS infections. OBJECTIVES:To provide an overview of clinical characteristics and risk f...

journal_title：European journal of neurology

authors： Sellner J,Trinka E

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:For Parkinson's disease (PD), an extended-release (ER) pramipexole formulation taken once daily, has shown efficacy, safety, and tolerability resembling those of immediate-release (IR) pramipexole taken three times daily. The present study assessed, in advanced PD, the success of an overnight swi...

journal_title：European journal of neurology

authors： Schapira AH,Barone P,Hauser RA,Mizuno Y,Rascol O,Busse M,Debieuvre C,Fraessdorf M,Poewe W

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Multiple sclerosis (MS) patients discontinuing natalizumab are at risk of rebound of disease activity. METHODS:In the present multi-center, open-label, non-randomized, prospective, pilot study, we tested whether treatment with glatiramer acetate (GA) is safe and effective after natalizumab in MS...

journal_title：European journal of neurology

authors： Rossi S,Motta C,Studer V,De Chiara V,Barbieri F,Monteleone F,Fornasiero A,Coarelli G,Bernardi G,Cutter G,Stüve O,Salvetti M,Centonze D

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Screening batteries to narrow down a target-at-risk population are essential for trials testing neuroprotective compounds aiming to delay or prevent onset of Parkinson's disease (PD). METHODS:The PRIPS study focuses on early detection of incident PD in 1847 at baseline PD-free subjects, and asse...

journal_title：European journal of neurology

authors： Berg D,Godau J,Seppi K,Behnke S,Liepelt-Scarfone I,Lerche S,Stockner H,Gaenslen A,Mahlknecht P,Huber H,Srulijes K,Klenk J,Fassbender K,Maetzler W,Poewe W,PRIPS study group.

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To evaluate the incidence and predictors of ischaemic recurrent stroke and the adverse events of antithrombotic therapy in patients with first intra- or extracranial vertebral artery dissection (VAD) who were treated with aspirin or oral anticoagulation (OA). METHODS:A 21-year database of consec...

journal_title：European journal of neurology

authors： Arauz A,Ruiz A,Pacheco G,Rojas P,Rodríguez-Armida M,Cantú C,Murillo-Bonilla L,Ruiz-Sandoval JL,Barinagarrementeria F

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To examine the frequencies and clinical characteristics of fallers and non-fallers at different stages of Parkinson's disease (PD). METHODS:The sample consisted of 232 patients in an unselected cross-sectional cohort of patients with PD, 207 newly diagnosed and drug naive patients and 175 contro...

journal_title：European journal of neurology

authors： Hiorth YH,Lode K,Larsen JP

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:A Task Force was convened by the EFNS/MDS-ES Scientist Panel on Parkinson's disease (PD) and other movement disorders to systemically review relevant publications on the diagnosis of PD. METHODS:Following the EFNS instruction for the preparation of neurological diagnostic guidelines, recommendation levels h...

journal_title：European journal of neurology

authors： Berardelli A,Wenning GK,Antonini A,Berg D,Bloem BR,Bonifati V,Brooks D,Burn DJ,Colosimo C,Fanciulli A,Ferreira J,Gasser T,Grandas F,Kanovsky P,Kostic V,Kulisevsky J,Oertel W,Poewe W,Reese JP,Relja M,Ruzicka E,Sc

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Various breathing abnormalities (Neurology 2009; 73: 1218) have been proposed as indicators for the introduction of non-invasive positive-pressure ventilation (NIV) in patients with amyotrophic lateral sclerosis (ALS). We were interested in the usefulness of symptoms of respiratory insufficiency and abnormal...

journal_title：European journal of neurology

authors： Leonardis L,Dolenc Grošelj L,Vidmar G

更新日期：2012-12-01 00:00:00